Berryllium and compounds RoHS Dossier

2020-4-21 · Figure 2-3: Beryllium flows from mining to end use stage (source: USGS 2016) 27 Figure 2-4: Simplified beryllium flows in the EU to end use stage 28 Figure 5-1: Rates of WEEE collected per EU country in 2016 34

Chronic Beryllium Disease: Update on a Moving Target ...

2020-12-1 · Beryllium exposure remains an ongoing occupational health concern for workers worldwide. Since the initial Occupational Safety and Health Administration (OSHA) ruling on a permissible exposure limit (PEL) for beryllium in 1971, our understanding of the risks of beryllium sensitization and chronic beryllium disease (CBD) has evolved substantially.

Release of beryllium from mineral ores in artificial lung ...

2011-8-25 · Beryllium is a lightweight metal, which is commercially extracted from two silicate minerals, bertrandite (Be 4 Si 2 O 7 (OH) 2) and beryl (Be 3 Al 2 Si 6 O …

Release of beryllium from mineral ores in artificial lung ...

Exposure to some manufactured beryllium compounds via skin contact or inhalation can cause sensitization. A portion of sensitized persons who inhale beryllium may develop chronic beryllium disease (CBD). Little is understood about exposures to naturally occurring beryllium minerals. The purpose of t …

Beryllium Sensitization Progresses to Chronic Beryllium ...

2004-2-13 · In the late 1980s and 1990s, several population-based studies of beryllium-exposed workers in the beryllium ceramics and nuclear weapons industries resulted in the resurrected use of a blood test designed to detect beryllium-specific T cell–proliferative responses in the blood of beryllium-exposed workers (1–9).This test, referred to as the beryllium lymphocyte proliferation test (BeLPT ...

Flow cytometric test for beryllium sensitivity ...

Chronic beryllium disease (CBD) is a hypersensitivity granulomatous disease that predominantly affects the lungs ().Measurement of lymphocyte proliferative responses to beryllium using peripheral blood cells or cells obtained by bronchoalveolar lavage is the standard method of documenting beryllium sensitivity (1-3) tecting beryllium sensitivity has been useful as part of the diagnostic ...

Chronic Beryllium Disease

Chronic Beryllium Disease (CBD) is an occupation-related disease characterized by lung exposure to beryllium. it is also called berylliosis.. Beryllium is a naturally occurring lightweight material that can easily be inhaled in the forms of dust or fumes.

The chemistry and metallurgy of beryllium

2015-4-17 · lium disease (CBD) is a debilitating granulomatous lung disorder resulting from an uncontrolled cell-mediated immune response marked by the proliferation of the co4• T cells.4 The dissolution, speciation and exact mech­ anism by which beryllium particles trigger CBD is not clearly understood. Current molecular understanding of

Process-related risk of beryllium sensitization and ...

2005-3-1 · Background Chronic beryllium disease (CBD), which primarily affects the lungs, occurs in sensitized beryllium-exposed individuals. At a copper-beryllium alloy strip and wire finishing facility we performed a cross-sectional survey to examine prevalences of beryllium sensitization and CBD, and relationships between sensitization and CBD and work areas/processes.

CLINICAL GUIDELINE FOR THE DIAGNOSIS OF BERYLLIUM ...

2019-11-18 · The prevalence of sensitization to beryllium has been observed to vary by industry and job or process type.[6] Although studies of exposure-response are inconsistent, there is evidence of association between increased exposure to beryllium and developing CBD.[2] Medical literature shows beryllium exposure may be unrecognized, [2

Beryllium sensitization, chronic beryllium disease, and ...

In this study, we examine beryllium sensitization, chronic beryllium disease (CBD), and workplace exposures at a beryllium mining (mine) and extraction facility (mill) in Delta, Utah. Historical airborne beryllium data collected between 1970-1999 included general area (GA), breathing zone (BZ), and …

The Beryllium Advantage: Texas Rare Earth Resources and/or ...

2015-2-26 · Beryllium (Be) is a relatively rare element in both the universe and in the crust of the Earth. As a free element it is a steel-gray, strong, lightweight and brittle alkaline earth metal. Beryllium increases hardness and resistance to corrosion when alloyed with aluminium, cobalt, copper (notably beryllium copper), iron and nickel.

Beryllium | NC DOL

2021-8-20 · Beryllium. The element beryllium, atomic number 4, is a grey metal that is stronger than steel and lighter than aluminum. Its physical properties of great strength-to-weight, high melting point, excellent thermal stability and conductivity, reflectivity, and transparency to X-rays make it an essential material in the aerospace ...

Exposure-Response Analysis for Beryllium Sensitization and ...

The current occupational exposure limit (OEL) for beryllium has been in place for more than 50 years and was believed to be protective against chronic beryllium disease (CBD) until studies in the 1990s identified beryllium sensitization (BeS) and subclinical CBD in the absence of physical symptoms. Inconsistent sampling and exposure assessment methodologies have often prevented the ...

Solubility and Chemistry of Materials Encountered by ...

In this study, we examine beryllium sensitization, chronic beryllium disease (CBD), and workplace exposures at a beryllium mining (mine) and extraction facility (mill) in Delta, Utah.

Beryllium coordination chemistry and its implications on ...

duals with CBD have one distinct subtype of the MHCII. This receptor consists of four peptides: two a- and two b-chains. Only if a glutamic acid is at the 69th position of the b-chain beryllium exposure can result in CBD.23–25 It could also be shown that the beryllium species is bound within an acidic pocket formed by the MHCII/peptide complex.

BRMI | Therapeutics

CBD is an inflammation in the lungs that can occur when a person is exposed to respirable Be fumes, dusts or powder, and subsequently demonstrates an allergic reaction to beryllium. CBD is an occupational disease that may occur in the manufacture of metallic beryllium, beryllium oxide ceramic, or alloys containing Be.

Beryllium Oxide Digestion Optimization at the Savannah ...

2021-1-17 · issue centers on the potential for beryllium workers to develop Chronic Beryllium Disease (CBD)-a debilitating lung disorder affecting as many as 4.6% of past workers at nuclear weapons and beryllium mining facilities2• The majority of beryllium inhaled by an individual is cleared from the

Beryllium Sensitization, Chronic Beryllium Disease, and ...

2018-11-9 · In this study, we examine beryllium sensitization, chronic beryllium disease (CBD), and workplace exposures at a beryllium mining (mine) and extraction facility (mill) in Delta, Utah. Historical airborne beryllium data collected between 1970-1999 included general area (GA), breathing zone (BZ), and personal lapel (LP) measurements and ...

Chronic Beryllium Disease Finding Requires Reexamination ...

2021-6-1 · We read with interest the article by Frye et al1 published in CHEST (March 2021). We believe the evidence presented to justify an environmental beryllium exposure as causative of beryllium sensitization (BeS) and chronic beryllium disease (CBD) requires reexamination in light of the nonstandard beryllium lymphocyte proliferation test (BeLPT) methods.

Frequency of beryllium-specific, central memory CD4 T ...

2021-2-17 · Beryllium exposure can lead to the development of beryllium-specific CD4+ T cells and chronic beryllium disease (CBD), which is characterized by the presence of lung granulomas and a CD4+ T cell alveolitis. Studies have documented the presence of proliferating and cytokine-secreting CD4+ T cells in blood of CBD patients after beryllium stimulation.

Efficacy of a Program to Prevent Beryllium Sensitization ...

Copper-beryllium alloys, which generally contain ≤2% beryllium, are the most commonly used form of beryllium. 14 Published reports have shown that beryllium sensitization and CBD are associated with copper-beryllium alloy work. 4, 11, 12, 15 – 20 However, known or suspected concurrent or prior exposure to other sources of beryllium made it ...

Systematic review: progression of beryllium sensitization ...

2012-6-15 · With regard to research question 2 (Is the risk of CBD higher among beryllium-sensitized workers with ongoing beryllium exposure than among beryllium-sensitized workers whose beryllium exposure is ceased?), only two studies gave rudimentary information about the exposure status following the diagnosis of beryllium sensitization [11, 12].

Beryllium sensitization, chronic beryllium disease, and exposu…

Chronic Beryllium Disease

ROHS Annex II Dossier for Beryllium and its compounds ...

2019-9-25 · Table 2-3: Beryllium flows from mining to end use stage (source: USGS 2016) 25 Table 2-5: Simplified beryllium flows in the EU to end use stage 25 Table 2-5: Estimation of the amount of beryllium used in exemplary EEE-products 26 Table 3-1: Overview of existing OELs for beryllium and beryllium compounds in EU countries 28

3 Epidemiologic and Clinical Studies of Beryllium ...

Epidemiologic and Clinical Studies of Be Sensitization and CBD 59 Beryllium Mining and Extraction There is some information on the risk of CBD in workers in beryllium mining and extraction. In the United States, beryllium ore is mined in a single facility in Utah; …

3 Sensitization and Chronic Beryllium Disease | Health ...

2021-8-9 · Only a few studies have investigated the progression of BeS to CBD. They have been small and varied in design, exposure setting, length of followup, and diagnostic evaluation. In one of the earliest clinical studies to use the BeLPT, Rom et al. (1983) reported that 13 of 82 beryllium mining …

Beryllium Toxicity: Who Is at Risk of Exposure to ...

These individuals have a risk of developing chronic beryllium disease (CBD) in the future at a rate of 6% to 8% per year (Newman et al. 2005). In addition to total beryllium mass, factors such as chemical composition, particle size, number, and surface area may influence bioavailability of beryllium and contribute to risk of sensitization and ...

A Cluster of Beryllium Sensitization Traced to the ...

2020-9-11 · A beryllium-lymphocyte proliferation test (BeLPT) allows for the differentiation between sarcoidosis and CBD, especially in the setting of proven or suspected beryllium exposure. This test mimics the underlying pathophysiologic features of CBD by assessing T-cell proliferation in the presence of beryllium.

Copyright © 2007- ANC | Sitemap